CasNo： 86-58-8
MF： C9H8BNO2
Appearance： yellow crystal powder
-
The present invention concerns novel pyr...
The invention relates to a preparation m...
The invention relates to a preparation m...
Mechanical Allodynia (MA), a frequent ch...
8-bromoquinoline
Trimethyl borate
water
8-quinolinylboronic acid
| Conditions | Yield |
|---|---|
|
8-bromoquinoline;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 16h;
Trimethyl borate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 16h;
water;
In
tetrahydrofuran;
at 0 ℃;
|
87% |
|
8-bromoquinoline;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 16h;
Trimethyl borate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 16h;
water;
With
hydrogenchloride;
at 0 ℃;
|
87% |
iodo-8 quinoleine
Trimethyl borate
8-quinolinylboronic acid
| Conditions | Yield |
|---|---|
|
iodo-8 quinoleine;
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 4h;
Inert atmosphere;
Trimethyl borate;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 3h;
Inert atmosphere;
|
112 mg |
8-bromoquinoline
boric acid tributyl ester
8-amino quinoline
Triisopropyl borate
3-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-4-quinolin-8-yl-pyrrole-2,5-dione
