CasNo： 773-76-2
MF： C9H5Cl2NO
Appearance： light beige fluffy powder
|
Indications |
Chloroxine (Capitrol) shampoo contains a synthetic antibacterial compound similar to the hydroxyquinoline compounds used in dermatology for many years. |
|
Definition |
ChEBI: Quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. An synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp. |
|
Brand name |
Capitrol (Westwood- Squibb). |
|
Purification Methods |
Crystallise the dichloro-oxine from acetone/EtOH. [Beilstein 21 H 95.] |
InChI:InChI=1/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
N-Chloro-N-(phenylsulfonyl)benzene sulfo...
An operationally simple and metal-free p...
This article describes a simple, efficie...
8-Hydroxyquinoline derivatives are metal...
5,7-dichloro-8-quinolinyl-β-D-glucopyranoside
β-D-glucose
chloroxine
| Conditions | Yield |
|---|---|
|
With
β-glucosidase from almonds; water;
In
aq. phosphate buffer;
at 37 ℃;
for 0.666667h;
pH=7.4;
Reagent/catalyst;
Enzymatic reaction;
|
8-quinolinol
chloroxine
| Conditions | Yield |
|---|---|
|
With
N-chloro-N-(benzenesulfonyl)benzenesulfonamide;
In
acetonitrile;
at 20 - 25 ℃;
for 0.25h;
Green chemistry;
|
98.4% |
|
With
chlorine; acetic acid;
|
|
|
With
sulfur dichloride;
|
|
|
With
hydrogenchloride; iron(III) chloride;
|
|
|
With
disulfur dichloride;
|
|
|
Multi-step reaction with 2 steps
1: glacial acetic acid; chlorine
2: methanol
With
methanol; chlorine; acetic acid;
|
|
|
With
1-butyl-3-methyl-pyridinium dichloroiodate;
for 1h;
|
84 %Chromat. |
|
With
hydrogenchloride; water;
anschliessend mit Chlor, zuletzt bei 50-55grad;
|
8-quinolinol
broxyquinoline
5,7,7-trichloro-7H-quinoline-8-one
2,4-dichloro-6-nitrophenol
undec-10-enoic acid-(5,7-dichloro-[8]quinolyl ester)
benzoic acid-(5,7-dichloro-[8]quinolyl ester)
7-chloro-5-(4'-diethylamino-2'-methylphenylimino)quinoline-8-one
7-chloro-5-(4'-dimethylaminophenylimino)quinoline-8-one
