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  • Product Name5-Chloro-8-hydroxyquinoline
  • CasNo. 130-16-5
  • MFC9H6ClNO
  • MW179.606
  • Purity
  • Appearancelight green to grey powder
  • Packing
  • Contact usInquiry

Product Details

CasNo： 130-16-5

MF： C9H6ClNO

Appearance： light green to grey powder

Factory Sells Best Quality 5-Chloro-8-hydroxyquinoline 130-16-5 with steady supply

  • Molecular Formula:C9H6ClNO
  • Molecular Weight:179.606
  • Appearance/Colour:light green to grey powder 
  • Vapor Pressure:2.46E-05mmHg at 25°C 
  • Melting Point:122-124 °C(lit.) 
  • Refractive Index:1.696 
  • Boiling Point:348.7 °C at 760 mmHg 
  • PKA:3.77±0.10(Predicted) 
  • Flash Point:164.7 °C 
  • PSA：33.12000 
  • Density:1.412 g/cm3 
  • LogP:2.59380 

5-Chloro-8-hydroxyquinoline(Cas 130-16-5) Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x

in vitro

Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.

in vivo

Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.

InChI:InChI=1/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H

130-16-5 Relevant articles

Nonreductive deiodination of ortho-iodo-hydroxylated arenes using tertiary amines

Talekar, Rahul Subhash,Chen, Grace Shiahuy,Lai, Shin-Yu,Chern, Ji-Wang

, p. 8590 - 8593 (2005)

A convenient and nonreductive deiodinati...

Glycosylated copper(ii) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy

Oliveri, Valentina,Viale, Maurizio,Caron, Giulia,Aiello, Cinzia,Gangemi, Rosaria,Vecchio, Graziella

, p. 2023 - 2034 (2013)

8-Hydroxyquinoline derivatives are metal...

A general method for the metal-free, regioselective, remote C-H halogenation of 8-substituted quinolines

Motati, Damoder Reddy,Uredi, Dilipkumar,Watkins, E. Blake

, p. 1782 - 1788 (2018/02/23)

An operationally simple and metal-free p...

Study on Relationship Between Fluorescence Properties and Structure of Substituted 8-Hydroxyquinoline Zinc Complexes

Jianbo, He,Tingting, Zhou,Yongjing, Cao,Yuanyuan, Zhang,Weiqing, Yang,Menglin, Ma

, p. 1121 - 1126 (2018/08/17)

Organic light-emitting diodes (OLEDs) pr...

Preparation method of 5-chloro-8-hydroxyquinoline

-

Paragraph 0040; 0041; 0049; 0051; 0053; 0055, (2018/07/15)

The invention discloses a preparation me...

Quinoline synthesis by improved Skraup-Doebner-Von Miller reactions utilizing acrolein diethyl acetal

Ramann, Ginelle A.,Cowen, Bryan J.

supporting information, p. 6436 - 6439 (2015/11/16)

A robust synthetic method has been devel...

130-16-5 Process route

5-chloro-8-quinolinyl-β-D-glucopyranoside
101111-68-6

5-chloro-8-quinolinyl-β-D-glucopyranoside

β-D-glucose
492-61-5

β-D-glucose

5-Chloro-8-hydroxyquinoline
130-16-5

5-Chloro-8-hydroxyquinoline

Conditions
Conditions Yield
With β-glucosidase from almonds; water; In aq. phosphate buffer; at 37 ℃; for 0.666667h; pH=7.4; Reagent/catalyst; Enzymatic reaction;
chloroxine
773-76-2

chloroxine

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

β-D-glucose
492-61-5

β-D-glucose

5-Chloro-8-hydroxyquinoline
130-16-5

5-Chloro-8-hydroxyquinoline

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: potassium carbonate; tetrabutylammomium bromide / methanol; water; dichloromethane / 68 h / 20 °C
2: β-glucosidase from almonds; water / aq. phosphate buffer / 0.67 h / 37 °C / pH 7.4 / Enzymatic reaction
With β-glucosidase from almonds; tetrabutylammomium bromide; water; potassium carbonate; In methanol; aq. phosphate buffer; dichloromethane; water; 1: |Michael Addition;

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